“Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures.” — Baytril manufacturer web page. Elanco, 2024. https://my.elanco.com/us/baytril (retrieved 2024-11-01)
“The use of fluoroquinolones in cats has been reported to adversely affect the retina. Such products should be used with caution in cats.” — Baytril manufacturer web page. Elanco, 2024. https://my.elanco.com/us/baytril (retrieved 2024-11-01)
Ford MM, Dubielzig RR, Giuliano EA, Moore CP, Narfström KL. Ocular and systemic manifestations after oral administration of a high dose of enrofloxacin in cats. Am J Vet Res. 2007 Feb;68(2):190-202. doi:10.2460/ajvr.68.2.190
Foster JD, Abouraya M, Papich MG, Muma NA. Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function. J Vet Intern Med. 2023 Nov-Dec;37(6):2230-2240. doi:10.1111/jvim.16866
Gelatt KN, van der Woerdt A, Ketring KL, Andrew SE, Brooks DE, Biros DJ, Denis HM, Cutler TJ. Enrofloxacin-associated retinal degeneration in cats. Vet Ophthalmol. 2001 Jun;4(2):99-106. doi:10.1046/j.1463-5224.2001.00182.x
Hwang YH, Kim MS, Song IB, Lim JH, Park BK, Yun HI. Altered pharmacokinetics of enrofloxacin in experimental models of hepatic and renal impairment. Vet Res Commun. 2009 Jun;33(5):481-7. doi:10.1007/s11259-008-9195-y
“Avoid enrofloxacin in cats with CKD due to increased risk of retinopathy at standard therapeutic doses” — Sparkes AH, Caney S, Chalhoub S, Elliott J, Finch N, Gajanayake I, Langston C, Lefebvre HP, White J, Quimby J. ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease. J Feline Med Surg. 2016 Mar;18(3):219-39. doi:10.1177/1098612X16631234 (retrieved 2024-04-02)
“Dosage adjustments may be particularly important for enrofloxacin, which appears to be more retinotoxic in cats” — Trepanier LA. Feline Therapeutics. World Small Animal Veterinary Association World Congress Proceedings, 2013. https://www.vin.com/doc/?id=5709852 (retrieved 2024-11-01)
Wiebe V, Hamilton P. Fluoroquinolone-induced retinal degeneration in cats. J Am Vet Med Assoc. 2002 Dec 1;221(11):1568-71. doi:10.2460/javma.2002.221.1568
Dad says this tastes sweet, but I don’t notice it in my food. We’re hopeful it’s helping to prevent certain kinds of UTIs. I had a UTI not so long ago, and let me tell you, that was no fun!
I’ll never understand it, but Dad likes to monitor my litter box habits. (I know, right?!) This tells him when I use the box, what I did (#1 or #2), how long I was in there, and even my weight! Heck, just monitoring my weight day-to-day is extremely valuable. But my dad also geeks out on all the stats and other info. 🤓
🟢 VRS flo cat (powder, 90 g)
Promote optimal urinary tract health and function.
Albarellos GA, Montoya L, Landoni MF. Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats. Vet J. 2005 Sep;170(2):222-9. doi:10.1016/j.tvjl.2004.05.011
“Adjust dose in moderate or severe CKD (IRIS stages 3 and 4)” — Sparkes AH, Caney S, Chalhoub S, Elliott J, Finch N, Gajanayake I, Langston C, Lefebvre HP, White J, Quimby J. ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease. J Feline Med Surg. 2016 Mar;18(3):219-39. doi:10.1177/1098612X16631234 (retrieved 2024-04-02)
“Fluoroquinolones … are renally cleared. … they do cause dose-dependent retinal toxicity in cats. Therefore, dosage adjustments for fluoroquinolones may be important in cats with renal insufficiency … extending the dosing interval may be most appropriate, since fluoroquinolones are also concentration-dependent.” — Trepanier LA. Feline Therapeutics. World Small Animal Veterinary Association World Congress Proceedings, 2013. https://www.vin.com/doc/?id=5709852 (retrieved 2024-11-01)
Wiebe V, Hamilton P. Fluoroquinolone-induced retinal degeneration in cats. J Am Vet Med Assoc. 2002 Dec 1;221(11):1568-71. doi:10.2460/javma.2002.221.1568
“Quinolones should be used with caution in animals with known or suspected central nervous system (CNS) disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures.” — Zeniquin product insert. Zoetis, 2019. PDF (retrieved 2024-11-01)
“The use of fluoroquinolones in cats has been reported to adversely affect the retina. Such products should be used with caution in cats.” — Zeniquin product insert. Zoetis, 2019. PDF (retrieved 2024-11-01)
UTI references and resources
Dorsch R, Teichmann-Knorrn S, Sjetne Lund H. Urinary tract infection and subclinical bacteriuria in cats: A clinical update. Journal of Feline Medicine and Surgery. 2019;21(11):1023-1038. doi:10.1177/1098612X19880435