CKD

Updated March 28, 2025.

🟢 Dechra Porus One

Dechra Porus One

CKD

Enteric dialysis

manufacturer page  Tanya’s info 

View on VetRxDirect 

😺 Luna Says

Dad is really excited about this one, but I don’t get what’s the big deal. Some mumbo-jumbo about absorbing uremic toxin precursors in the gut before they get into my blood. Apparently that helps me feel better! He says it’s one of the few supplements available that repeatedly demonstrates a benefit when studied by researchers.

References and resources
  1. Mottet J, Kowollik, N. Renaltec attenuates serum levels of indoxyl sulfate in geriatric cats. BSAVA Congress Proceedings 2019. doi:10.22233/9781910443699.58.2 
  2. Paschall RE, Quimby JM, Lourenço BN, Summers SC, Schmiedt CW. The Effect of Renaltec on Serum Uremic Toxins in Cats with Experimentally Induced Chronic Kidney Disease. Veterinary Sciences. 2024; 11(8):379. doi:10.3390/vetsci11080379 

🟢 Petivity by Purina Petivity Smart Litter Box Monitor

Petivity by Purina Petivity Smart Litter Box Monitor

CKD

Monitoring

UTI

manufacturer page 

View on Amazon  💲 | Chewy  | Direct 

😺 Luna Says

I’ll never understand it, but Dad likes to monitor my litter box habits. (I know, right?!) This tells him when I use the box, what I did (#1 or #2), how long I was in there, and even my weight! Heck, just monitoring my weight day-to-day is extremely valuable. But my dad also geeks out on all the stats and other info. 🤓

🟢 Rapamycin for Cats

CKD

Drugs

Heart

View on Helping Pets Live Longer 

References and resources
  1. Kaplan JL, Rivas VN, Walker AL, Grubb L, Farrell A, Fitzgerald S, Kennedy S, Jauregui CE, Crofton AE, McLaughlin C, Van Zile R, DeFrancesco TC, Meurs KM, Stern JA. Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic cardiomyopathy: results of the RAPACAT trial. J Am Vet Med Assoc. 2023 Jul 26;261(11):1628-1637. doi:10.2460/javma.23.04.0187 

🟢 ThorneVET Kidney Support Formula

ThorneVET Kidney Support Formula

CKD

Supplements

Soft Chews

View on ThorneVET 

Powder

View on ThorneVET 

🟢 Virbac Nephrodyl Synbiotic Capsules

Virbac Nephrodyl Synbiotic Capsules

CKD

Enteric dialysis

manufacturer page 

View on Chewy 

😺 Luna Says

This is another one Dad’s excited about, but I haven’t really tried it in earnest yet. The pills are so slippery, I just lick the treat right around them and leave the pill. I’m sneaky like that.

CKD references and resources

  1. Hypertension, chronic kidney disease and the renin-angiotensin-aldosterone system (2020). American Animal Hospital Association. https://www.aaha.org/wp-content/uploads/globalassets/05-pet-health-resources/critical-connections_web.pdf 
  2. Broome M. Feline Hyperthyroidism - Avoiding Further Renal Injury. 2010. https://www.researchgate.net/publication/265349615Feline_Hyperthyroidism-Avoiding_Further_Renal_Injury 
  3. Cabała S, Ożgo M, Herosimczyk A. The Kidney-Gut Axis as a Novel Target for Nutritional Intervention to Counteract Chronic Kidney Disease Progression. Metabolites. 2024 Jan 22;14(1):78. doi:10.3390/metabo14010078 
  4. Cline MG. Nutritional Management of Chronic Kidney Disease in Cats & Dogs. Today’s Veterinary Practice. 2016. https://todaysveterinarypractice.com/nutrition/acvn-nutrition-notesnutritional-management-of-chronic-kidney-disease-in-cats-dogs 
  5. Coleman A, Elliott J. Inhibition of the renin-angiotensin-aldosterone system in cats and dogs: The emerging role of angiotensin II receptor blockers. International Renal Interest Society (IRIS). 2022. http://www.iris-kidney.com/education/renin-anglotensin-aldosterone-system.html 
  6. Cook A, Saunders A. Finding the Balance in Your Patients with Cardiovascular and Renal Disease. Today’s Veterinary Practice. 2018. https://todaysveterinarypractice.com/cardiology/veterinary-patients-with-cardiovascular-and-renal-disease/ 
  7. Daminet S. How to Treat a Cat with Hyperthyroidism and Concurrent Renal Insufficiency? World Small Animal Veterinary Association World Congress Proceedings, 2010. https://www.vin.com/doc/?id=4516305 
  8. Chronic Kidney Disease/Hyperthyroidism/Iodine 131: Considerations and therapeutic options that enhance our success. Feline Hyperthyroid Treatment Center. 2014. https://www.felinehtc.com/documents/Chronic-Kidney-Disease_Hyperthyroidism_Iodine-131-Fall-2014.pdf 
  9. Fitzpatrick, R. L., Wittenburg, L. A., Hansen, R. J., Gustafson, D. L., Quimby, J. M. Limited sampling pharmacokinetics of subcutaneous ondansetron in healthy geriatric cats, cats with chronic kidney disease, and cats with liver disease. J. vet. Pharmacol. Therap. doi:10.1111/jvp.12286 
  10. Heine GH, Seiler S, Fliser D. FGF-23: the rise of a novel cardiovascular risk marker in CKD. Nephrol Dial Transplant. 2012 Aug;27(8):3072-81. doi:10.1093/ndt/gfs259 
  11. Ishikawa, A., Kawarazaki, H., Ando, K. et al. Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. Clin Exp Nephrol 15, 30-33 (2011). doi:10.1007/s10157-010-0350-8 
  12. Izuhara Y, Nangaku M, Inagi R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de Strihou C, Miyata T. Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering. J Am Soc Nephrol. 2005 Dec;16(12):3631-41. doi:10.1681/ASN.2005050522 
  13. Kobori H, Mori H, Masaki T, Nishiyama A. Angiotensin II blockade and renal protection. Curr Pharm Des. 2013;19(17):3033-42. doi:10.2174/1381612811319170009 
  14. Lawson JS, Jepson RE. Feline comorbidities: The intermingled relationship between chronic kidney disease and hypertension. Journal of Feline Medicine and Surgery. 2021;23(9):812-822. doi:10.1177/1098612X211037872 
  15. Le Garreres A, Laroute V, De La Farge F, Boudet KG, Lefebvre HP. Disposition of plasma creatinine in non-azotaemic and moderately azotaemic cats. Journal of Feline Medicine and Surgery. 2007;9(2):89-96. doi:10.1016/j.jfms.2006.08.003 
  16. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Erdine S, Kiowski W, Agabiti-Rosei E, Ambrosioni E, Lindholm LH, Viigimaa M, Adamopoulos S, Agabiti-Rosei E, Ambrosioni E, Bertomeu V, Clement D, Erdine S, Farsang C, Gaita D, Lip G, Mallion JM, Manolis AJ, Nilsson PM, O’Brien E, Ponikowski P, Redon J, Ruschitzka F, Tamargo J, van Zwieten P, Waeber B, Williams B; Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007 Jun;25(6):1105-87. doi:10.1097/HJH.0b013e3281fc975a 
  17. Nambulli S, Rennick LJ, Acciardo AS, Tilston-Lunel NL, Ho G, Crossland NA, Hardcastle K, Nieto B, Bainbridge G, Williams T, Sharp CR, Duprex WP. FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2209405119. doi:10.1073/pnas.2209405119 
  18. Peterson ME. Dietary Management of Cats with Kidney Disease After Treatment with Radioiodine for Hyperthyroidism. Animal Endocrine Clinic and Hypurrcat. 2015. https://www.animalendocrine.com/wp-content/uploads/2015/05/Dietary-Management-of-Cats-with-Hyperthyroidism-Concurrent-Renal-Disease-Final.pdf 
  19. Quimby, J.M., Gustafson, D.L. and Lunn, K.F. (2011), The Pharmacokinetics of Mirtazapine in Cats with Chronic Kidney Disease and In Age-Matched Control Cats. J Vet Intern Med, 25: 985-989. doi:10.1111/j.1939-1676.2011.00780.x 
  20. Quimby JM, Lunn KF. Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. Vet J. 2013 Sep;197(3):651-5. doi:10.1016/j.tvjl.2013.05.048 
  21. Quimby JM, Benson KK, Summers SC, et al. Assessment of compounded transdermal mirtazapine as an appetite stimulant in cats with chronic kidney disease. Journal of Feline Medicine and Surgery. 2020;22(4):376-383. doi:10.1177/1098612X19851303 
  22. Quimby JM, Lorbach SK, Saffire A, et al. Serum concentrations of gabapentin in cats with chronic kidney disease. Journal of Feline Medicine and Surgery. 2022;24(12):1260-1266. doi:10.1177/1098612X221077017 
  23. Sent, U., Gössl, R., Elliott, J., Syme, H.M. and Zimmering, T. (2015), Comparison of Efficacy of Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease. J Vet Intern Med, 29: 1479-1487. doi:10.1111/jvim.13639 
  24. Sparkes AH, Caney S, Chalhoub S, Elliott J, Finch N, Gajanayake I, Langston C, Lefebvre HP, White J, Quimby J. ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease. J Feline Med Surg. 2016 Mar;18(3):219-39. doi:10.1177/1098612X16631234 
  25. Sueyoshi M, Fukunaga M, Mei M, Nakajima A, Tanaka G, Murase T, Narita Y, Hirata S, Kadowaki D. Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats. Clin Exp Nephrol. 2019 Jul;23(7):908-919. doi:10.1007/s10157-019-01727-4 
  26. Syme HM. Cardiovascular and renal manifestations of hyperthyroidism. Vet Clin North Am Small Anim Pract. 2007 Jul;37(4):723-43, vi. doi:10.1016/j.cvsm.2007.05.011 
  27. Vaske HH, Schermerhorn T, Grauer GF. Effects of feline hyperthyroidism on kidney function: a review. Journal of Feline Medicine and Surgery. 2016;18(2):55-59. doi:10.1177/1098612X15575385 
  28. Wohlfahrt P, Melenovsky V, Kotrc M, Benes J, Jabor A, Franekova J, Lemaire S, Kautzner J, Jarolim P. Association of Fibroblast Growth Factor-23 Levels and Angiotensin-Converting Enzyme Inhibition in Chronic Systolic Heart Failure. JACC Heart Fail. 2015 Oct;3(10):829-39. doi:10.1016/j.jchf.2015.05.012 
  29. Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA. 2002 Nov 20;288(19):2421-31. doi:10.1001/jama.288.19.2421 
  30. Yu, L., Lacorcia, L. and Johnstone, T., Hyperthyroid cats and their kidneys: a literature review. Aust Vet J. 2022; 100: 415-432. doi:10.1111/avj.13179 
  31. Zhang Y, He D, Zhang W, Xing Y, Guo Y, Wang F, Jia J, Yan T, Liu Y, Lin S. ACE Inhibitor Benefit to Kidney and Cardiovascular Outcomes for Patients with Non-Dialysis Chronic Kidney Disease Stages 3-5: A Network Meta-Analysis of Randomised Clinical Trials. Drugs. 2020 Jun;80(8):797-811. doi:10.1007/s40265-020-01290-3 

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