Keeping tabs on blood pressure is super important for a CKD kitty like me! This device, plus regular vet visits, help make sure my blood pressure is just right.
“This study failed to identify an effect of subclinical HCM on owner assessed QOL or activity, or a treatment effect of atenolol on these variables at the dosage evaluated. These findings do not support a treatment benefit of atenolol for the goal of symptom reduction in cats with subclinical HCM.” — Coleman AE, DeFrancesco TC, Griffiths EH, Lascelles BDX, Kleisch DJ, Atkins CE, Keene BW. Atenolol in cats with subclinical hypertrophic cardiomyopathy: a double-blind, placebo-controlled, randomized clinical trial of effect on quality of life, activity, and cardiac biomarkers. J Vet Cardiol. 2020 Aug;30:77-91. doi:10.1016/j.jvc.2020.06.002 (retrieved 2025-05-08)
“If a cat is receiving beta-blockers (e.g., for previously diagnosed HCM with LVOTO), the dose should be carefully down-titrated or even stopped after a few weeks. This is because the intense neuroendocrine activation of CHF includes increased sympathetic drive to maintain cardiac output; beta-blockade may prevent some of this compensatory effort. However, the decision about discontinuing beta-blockers depends on each individual case (e.g., if there is significant LVOTO). Beta-blockers should never be started in a cat presenting with uncontrolled CHF; an interim analysis of heart failure treatments indicated significantly reduced survival in cats receiving this class of drug.” — Dukes-McEwan J, Partington C. Management of the cat with heart failure. Royal Canin Academy web site. 2022. https://academy.royalcanin.com/en/veterinary/management-of-the-cat-with-heart-failure (retrieved 2025-05-08)
“…at interim analysis, there was little evidence to suggest that chronic administration of furosemide plus either atenolol, dilacor, or enalapril at doses specified, provided any major advantage in clinical outcome versus administration of furosemide alone.” — Fox PR. Prospective, double-blinded, multicenter evaluation of chronic therapies for feline diastolic heart failure: interim analysis. Research Abstract Program of the 21st Annual ACVIM Forum Charlotte, NC, June 4-7, 2003. Journal of Veterinary Internal Medicine, 17: 398-399. doi:10.1111/j.1939-1676.2003.tb02465.x (retrieved 2025-05-08)
Jensen J, Henik RA, Brownfield M, Armstrong J. Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease. Am J Vet Res. 1997 May;58(5):535-40. doi:10.2460/ajvr.1997.58.05.535
“Atenolol administration did not decrease NT-proBNP or cTnI concentrations in cats with severe left ventricular hypertrophy caused by hypertrophic cardiomyopathy. These results suggest that atenolol did not decrease myocardial ischemia and myocyte death in these cats.” — Jung, S.W. and Kittleson, M.D. (2011), The Effect of Atenolol on NT-proBNP and Troponin in Asymptomatic Cats with Severe Left Ventricular Hypertrophy because of Hypertrophic Cardiomyopathy: A Pilot Study. Journal of Veterinary Internal Medicine, 25: 1044-1049. doi:10.1111/j.1939-1676.2011.0754.x (retrieved 2025-05-08)
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Ogawa M, Kawamura A, Akabane R, Sakatani A, Miyakawa H, Hsu H-H, et al. Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: a pilot study. Vet Rec Open. 2022; 9:e28. doi:10.1002/vro2.28
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Riesen, S.C., Schober, K.E., Cervenec, R.M. and Bonagura, J.D. (2011), Comparison of the Effects of Ivabradine and Atenolol on Heart Rate and Echocardiographic Variables of Left Heart Function in Healthy Cats. Journal of Veterinary Internal Medicine, 25: 469-476. doi:10.1111/j.1939-1676.2011.0705.x
“Our study failed to demonstrate an effect of atenolol on 5-year survival in cats with preclinical HCM.” — Schober KE, Zientek J, Li X, Fuentes VL, Bonagura JD. Effect of treatment with atenolol on 5-year survival in cats with preclinical (asymptomatic) hypertrophic cardiomyopathy. J Vet Cardiol. 2013 Jun;15(2):93-104. doi:10.1016/j.jvc.2013.03.003 (retrieved 2025-05-08)
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Carter J. Hypertensive ocular disease in cats: A guide to fundic lesions to facilitate early diagnosis. Journal of Feline Medicine and Surgery. 2019;21(1):35-45. doi:10.1177/1098612X18818668
Coleman AE, Brown SA, Traas AM, Bryson L, Zimmering T, Zimmerman A. Safety and efficacy of orally administered telmisartan for the treatment of systemic hypertension in cats: Results of a double-blind, placebo-controlled, randomized clinical trial. J Vet Intern Med. 2019; 33: 478-488. doi:10.1111/jvim.15429
Garcia Marrero TM, Ward JL, Tropf MA, Bourgois-Mochel A, Guillot E, Domenig O, Yuan L, Kundu D, Mochel JP. Effect of amlodipine on the circulating renin-angiotensin-aldosterone system in healthy cats. J Vet Intern Med. 2024 Mar-Apr;38(2):913-921. doi:10.1111/jvim.17006
Glaus TM, Elliott J, Herberich E, Zimmering T, Albrecht B. Efficacy of long-term oral telmisartan treatment in cats with hypertension: Results of a prospective European clinical trial. J Vet Intern Med. 2019; 33: 413-422. doi:10.1111/jvim.15394
Hampton A, Ford A, Cox RE 3rd, Liu CC, Koh R. Effects of music on behavior and physiological stress response of domestic cats in a veterinary clinic. J Feline Med Surg. 2020 Feb;22(2):122-128. doi:10.1177/1098612X19828131
Izuhara Y, Nangaku M, Inagi R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de Strihou C, Miyata T. Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering. J Am Soc Nephrol. 2005 Dec;16(12):3631-41. doi:10.1681/ASN.2005050522
Jepson, R.E., Syme, H.M. and Elliott, J. (2014), Plasma Renin Activity and Aldosterone Concentrations in Hypertensive Cats with and without Azotemia and in Response to Treatment with Amlodipine Besylate. J Vet Intern Med, 28: 144-153. doi:10.1111/jvim.12240
Kobori H, Mori H, Masaki T, Nishiyama A. Angiotensin II blockade and renal protection. Curr Pharm Des. 2013;19(17):3033-42. doi:10.2174/1381612811319170009
Kothari N, Ganguly B (2014). Potential Drug-Drug Interactions among Medications Prescribed to Hypertensive Patients. J Clin of Diagn Res. 8(11), HC01-HC04. doi:10.7860/JCDR/2014/10032.5091
Lalor SM, Connolly DJ, Elliott J, Syme HM. Plasma concentrations of natriuretic peptides in normal cats and normotensive and hypertensive cats with chronic kidney disease. J Vet Cardiol. 2009 May;11 Suppl 1:S71-9. doi:10.1016/j.jvc.2009.01.004
Lawson JS, Jepson RE. Feline comorbidities: The intermingled relationship between chronic kidney disease and hypertension. Journal of Feline Medicine and Surgery. 2021;23(9):812-822. doi:10.1177/1098612X211037872
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Maggio F, DeFrancesco TC, Atkins CE, Pizzirani S, Gilger BC, Davidson MG. Ocular lesions associated with systemic hypertension in cats: 69 cases (1985-1998). J Am Vet Med Assoc. 2000 Sep 1;217(5):695-702. doi:10.2460/javma.2000.217.695
Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Erdine S, Kiowski W, Agabiti-Rosei E, Ambrosioni E, Lindholm LH, Viigimaa M, Adamopoulos S, Agabiti-Rosei E, Ambrosioni E, Bertomeu V, Clement D, Erdine S, Farsang C, Gaita D, Lip G, Mallion JM, Manolis AJ, Nilsson PM, O’Brien E, Ponikowski P, Redon J, Ruschitzka F, Tamargo J, van Zwieten P, Waeber B, Williams B; Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007 Jun;25(6):1105-87. doi:10.1097/HJH.0b013e3281fc975a
Mika MISHINA, Nobuyoshi WATANABE, Toshifumi WATANABE, Diurnal Variations of Blood Pressure in Cats, Journal of Veterinary Medical Science, 2006, Volume 68, Issue 3, Pages 243-248. doi:10.1292/jvms.68.243
Quimby JM, Jones SE, Saffire A, et al. Assessment of the effect of gabapentin on blood pressure in cats with and without chronic kidney disease. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241240326
Sent, U., Gössl, R., Elliott, J., Syme, H.M. and Zimmering, T. (2015), Comparison of Efficacy of Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease. J Vet Intern Med, 29: 1479-1487. doi:10.1111/jvim.13639
Taylor SS, Sparkes AH, Briscoe K, et al. ISFM Consensus Guidelines on the Diagnosis and Management of Hypertension in Cats. Journal of Feline Medicine and Surgery. 2017;19(3):288-303. doi:10.1177/1098612X17693500
Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA. 2002 Nov 20;288(19):2421-31. doi:10.1001/jama.288.19.2421
Zhang Y, He D, Zhang W, Xing Y, Guo Y, Wang F, Jia J, Yan T, Liu Y, Lin S. ACE Inhibitor Benefit to Kidney and Cardiovascular Outcomes for Patients with Non-Dialysis Chronic Kidney Disease Stages 3-5: A Network Meta-Analysis of Randomised Clinical Trials. Drugs. 2020 Jun;80(8):797-811. doi:10.1007/s40265-020-01290-3
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