Druzhaeva N, Petrič AD, Tavčar-Kalcher G, Babič J, Nemec Svete A. Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease. Am J Vet Res. 2021 Apr;82(4):280-285. doi:10.2460/ajvr.82.4.280
Ishikawa, A., Kawarazaki, H., Ando, K. et al. Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. Clin Exp Nephrol 15, 30-33 (2011). doi:10.1007/s10157-010-0350-8
Sood B, Patel P, Keenaghan M. Coenzyme Q10. [Updated 2024 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK531491/
Jensen J, Henik RA, Brownfield M, Armstrong J. Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease. Am J Vet Res. 1997 May;58(5):535-40. doi:10.2460/ajvr.1997.58.05.535
Jung, S.W. and Kittleson, M.D. (2011), The Effect of Atenolol on NT-proBNP and Troponin in Asymptomatic Cats with Severe Left Ventricular Hypertrophy because of Hypertrophic Cardiomyopathy: A Pilot Study. Journal of Veterinary Internal Medicine, 25: 1044-1049. doi:10.1111/j.1939-1676.2011.0754.x
Macgregor JM, Rush JE, Rozanski EA, Boothe DM, Belmonte AA, Freeman LM. Comparison of pharmacodynamic variables following oral versus transdermal administration of atenolol to healthy cats. Am J Vet Res. 2008 Jan;69(1):39-44. doi:10.2460/ajvr.69.1.39
Ogawa M, Kawamura A, Akabane R, Sakatani A, Miyakawa H, Hsu H-H, et al. Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: a pilot study. Vet Rec Open. 2022; 9:e28. doi:10.1002/vro2.28
Quiñones M, Dyer DC, Ware WA, Mehvar R. Pharmacokinetics of atenolol in clinically normal cats. Am J Vet Res. 1996 Jul;57(7):1050-3. doi:10.2460/ajvr.1996.57.07.1050
Riesen, S.C., Schober, K.E., Cervenec, R.M. and Bonagura, J.D. (2011), Comparison of the Effects of Ivabradine and Atenolol on Heart Rate and Echocardiographic Variables of Left Heart Function in Healthy Cats. Journal of Veterinary Internal Medicine, 25: 469-476. doi:10.1111/j.1939-1676.2011.0705.x
Schober KE, Zientek J, Li X, Fuentes VL, Bonagura JD. Effect of treatment with atenolol on 5-year survival in cats with preclinical (asymptomatic) hypertrophic cardiomyopathy. J Vet Cardiol. 2013 Jun;15(2):93-104. doi:10.1016/j.jvc.2013.03.003
Keisuke SUGIMOTO, Takuma AOKI, Yoko FUJII, Effects of atenolol on left atrial and left ventricular function in healthy cats and in cats with hypertrophic cardiomyopathy, Journal of Veterinary Medical Science, 2020, Volume 82, Issue 5, Pages 546-552. doi:10.1292/jvms.19-0670
Waterman M (2018). Pharmacodynamic evaluation of beta-blockade associated with atenolol in healthy dogs. Master’s Thesis, Virginia Polytechnic Institute and State University. http://hdl.handle.net/10919/97339
Hanzlicek AS, Gehring R, Kukanich B, Kukanich KS, Borgarelli M, Smee N, Olson EE, Margiocco M. Pharmacokinetics of oral pimobendan in healthy cats. J Vet Cardiol. 2012 Dec;14(4):489-96. doi:10.1016/j.jvc.2012.06.002
Kittleson MD, Côté E. The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy. Journal of Feline Medicine and Surgery. 2021;23(11):1028-1051. doi:10.1177/1098612X211020162
Oldach MS, Ueda Y, Ontiveros ES, Fousse SL, Harris SP and Stern JA (2019) Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study. Front. Vet. Sci. 6:15. doi:10.3389/fvets.2019.00015
Oldach, M.S., Ueda, Y., Ontiveros, E.S. et al. Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy. BMC Vet Res 17, 89 (2021). doi:10.1186/s12917-021-02799-9
Reina-Doreste Y, Stern JA, Keene BW, Tou SP, Atkins CE, DeFrancesco TC, Ames MK, Hodge TE, Meurs KM. Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure. J Am Vet Med Assoc. 2014 Sep 1;245(5):534-9. doi:10.2460/javma.245.5.534
Schober KE, Rush JE, Luis Fuentes V, et al. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study. J Vet Intern Med. 2021; 35: 789-800. doi:10.1111/jvim.16054
“Do no use simultaneously with anticoagulants, antihypertensive, vasodilators, or if suffering from ulcers, diabetes and when pregnant or breastfeeding.” — Cunha J. Forskolin. https://www.rxlist.com/forskolin/generic-drug.htm (retrieved 2024-10-20)
“Because supplementation with Coleus forskohlii extract or forskolin has been noted to reduce blood pressure, increase stomach acid levels, and inhibit platelet aggregation, it should be used with caution by people with hypotension (low blood pressure) or who are taking antihypertensive (blood-pressure-lowering) drugs, people with blood clotting disorders or who are taking blood thinning medication, and people with stomach ulcers.” — Damianou A, Milazzo N (2024). Coleus forskohlii. https://examine.com/supplements/coleus-forskohlii/#dosage-information (retrieved 2024-10-20)
This works very well for smothering capsules, or even plain as a chaser after those nasty oral medicines. (Gross!) I heard Dad mumble something about low sodium and the cardiologist.
Hanzlicek AS, Gehring R, Kukanich B, Kukanich KS, Borgarelli M, Smee N, Olson EE, Margiocco M. Pharmacokinetics of oral pimobendan in healthy cats. J Vet Cardiol. 2012 Dec;14(4):489-96. doi:10.1016/j.jvc.2012.06.002
Kittleson MD, Côté E. The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy. Journal of Feline Medicine and Surgery. 2021;23(11):1028-1051. doi:10.1177/1098612X211020162
Oldach MS, Ueda Y, Ontiveros ES, Fousse SL, Harris SP and Stern JA (2019) Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study. Front. Vet. Sci. 6:15. doi:10.3389/fvets.2019.00015
Oldach, M.S., Ueda, Y., Ontiveros, E.S. et al. Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy. BMC Vet Res 17, 89 (2021). doi:10.1186/s12917-021-02799-9
Reina-Doreste Y, Stern JA, Keene BW, Tou SP, Atkins CE, DeFrancesco TC, Ames MK, Hodge TE, Meurs KM. Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure. J Am Vet Med Assoc. 2014 Sep 1;245(5):534-9. doi:10.2460/javma.245.5.534
Schober KE, Rush JE, Luis Fuentes V, et al. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study. J Vet Intern Med. 2021; 35: 789-800. doi:10.1111/jvim.16054
Amabile CM, Spencer AP. Keeping your patient with heart failure safe: a review of potentially dangerous medications. Arch Intern Med. 2004 Apr 12;164(7):709-20. doi:10.1001/archinte.164.7.709
Kittleson M. Treatment of Feline Hypertrophic Cardiomyopathy - Lost Dreams. World Small Animal Veterinary Association World Congress Proceedings, 2014. https://www.vin.com/doc/?id=7054765
Page RL 2nd, O’Bryant CL, Cheng D, Dow TJ, Ky B, Stein CM, Spencer AP, Trupp RJ, Lindenfeld J; American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical Cardiology; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Drugs That May Cause or Exacerbate Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2016 Aug 9;134(6):e32-69. doi:10.1161/CIR.0000000000000426
Pierce, K.V., Rush, J.E., Freeman, L.M., Cunningham, S.M. and Yang, V.K. (2017), Association between Survival Time and Changes in NT-proBNP in Cats Treated for Congestive Heart Failure. J Vet Intern Med, 31: 678-684. doi:10.1111/jvim.14690
Rivas VN, Kaplan JL, Kennedy SA, Fitzgerald S, Crofton AE, Farrell A, Grubb L, Jauregui CE, Grigorean G, Choi E, et al. Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study. Animals. 2023; 13(20):3184. doi:10.3390/ani13203184
Schaer M. Fluid Therapy for Critically Ill Dogs and Cats. World Small Animal Veterinary Association World Congress Proceedings, 2006. https://www.vin.com/doc/?id=3858919
Syme HM. Cardiovascular and renal manifestations of hyperthyroidism. Vet Clin North Am Small Anim Pract. 2007 Jul;37(4):723-43, vi. doi:10.1016/j.cvsm.2007.05.011