Heart

Updated March 28, 2025.

🟢 Doctor’s Best Nattokinase 2,000 FU (90 ct)

Doctor's Best Nattokinase 2,000 FU

Heart

View on Amazon  💲 | Vitacost  | Doctor’s Best 

References and resources
  1. Chen H, McGowan EM, Ren N, Lal S, Nassif N, Shad-Kaneez F, Qu X, Lin Y. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018 Jul 5;13:1177271918785130. doi:10.1177/1177271918785130 
  2. Chen H, Chen J, Zhang F, Li Y, Wang R, Zheng Q, Zhang X, Zeng J, Xu F, Lin Y. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022 Aug 22;9:964977. doi: 10.3389/fcvm.2022.964977. Erratum in: Front Cardiovasc Med. 2022 Dec 05;9:1076420. doi:10.3389/fcvm.2022.1076420 
  3. Di Micco, P., Bernardi, F. F., Camporese, G., Biglietto, M., Perrella, A., Ciarambino, T., Russo, V., & Imbalzano, E. (2023). Nattokinase historical sketch on experimental and clinical evidence. Italian Journal of Medicine, 17(1). doi:10.4081/itjm.2023.1583 
  4. Raiszadeh MM. Compositions and methods for thromboembolism dissolution. World Intellectual Property Organization patent WO 2017/205790 A1. 2017 Nov 30. WO 2017/205790 A1 
  5. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43. doi:10.1159/000205051 
  6. Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28;18(3):523. doi:10.3390/ijms18030523 

🟢 Doctor’s Best Ubiquinol with Kaneka QH, 50 mg (90 ct)

Doctor's Best Ubiquinol with Kaneka QH, 50 mg

Heart

View on Amazon  💲 | Vitacost  | Doctor’s Best 

References and resources
  1. Druzhaeva N, Petrič AD, Tavčar-Kalcher G, Babič J, Nemec Svete A. Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease. Am J Vet Res. 2021 Apr;82(4):280-285. doi:10.2460/ajvr.82.4.280 
  2. Ishikawa, A., Kawarazaki, H., Ando, K. et al. Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. Clin Exp Nephrol 15, 30-33 (2011). doi:10.1007/s10157-010-0350-8 
  3. Sood B, Patel P, Keenaghan M. Coenzyme Q10. [Updated 2024 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK531491/ 

🟢 Generic Atenolol Compounded Oral Oil Liquid

Generic Atenolol Compounded Oral Oil Liquid

Blood pressure

Drugs

Heart

View on Chewy 

References and resources
  1. Drug Handout: Atenolol. CVCA. 2016. https://www.cvcavets.com/drug-handouts/atenolol/ 
  2. Jensen J, Henik RA, Brownfield M, Armstrong J. Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease. Am J Vet Res. 1997 May;58(5):535-40. doi:10.2460/ajvr.1997.58.05.535 
  3. Jung, S.W. and Kittleson, M.D. (2011), The Effect of Atenolol on NT-proBNP and Troponin in Asymptomatic Cats with Severe Left Ventricular Hypertrophy because of Hypertrophic Cardiomyopathy: A Pilot Study. Journal of Veterinary Internal Medicine, 25: 1044-1049. doi:10.1111/j.1939-1676.2011.0754.x 
  4. Macgregor JM, Rush JE, Rozanski EA, Boothe DM, Belmonte AA, Freeman LM. Comparison of pharmacodynamic variables following oral versus transdermal administration of atenolol to healthy cats. Am J Vet Res. 2008 Jan;69(1):39-44. doi:10.2460/ajvr.69.1.39 
  5. Ogawa M, Kawamura A, Akabane R, Sakatani A, Miyakawa H, Hsu H-H, et al. Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: a pilot study. Vet Rec Open. 2022; 9:e28. doi:10.1002/vro2.28 
  6. Quiñones M, Dyer DC, Ware WA, Mehvar R. Pharmacokinetics of atenolol in clinically normal cats. Am J Vet Res. 1996 Jul;57(7):1050-3. doi:10.2460/ajvr.1996.57.07.1050 
  7. Riesen, S.C., Schober, K.E., Cervenec, R.M. and Bonagura, J.D. (2011), Comparison of the Effects of Ivabradine and Atenolol on Heart Rate and Echocardiographic Variables of Left Heart Function in Healthy Cats. Journal of Veterinary Internal Medicine, 25: 469-476. doi:10.1111/j.1939-1676.2011.0705.x 
  8. Schober KE, Zientek J, Li X, Fuentes VL, Bonagura JD. Effect of treatment with atenolol on 5-year survival in cats with preclinical (asymptomatic) hypertrophic cardiomyopathy. J Vet Cardiol. 2013 Jun;15(2):93-104. doi:10.1016/j.jvc.2013.03.003 
  9. Keisuke SUGIMOTO, Takuma AOKI, Yoko FUJII, Effects of atenolol on left atrial and left ventricular function in healthy cats and in cats with hypertrophic cardiomyopathy, Journal of Veterinary Medical Science, 2020, Volume 82, Issue 5, Pages 546-552. doi:10.1292/jvms.19-0670 
  10. Waterman M (2018). Pharmacodynamic evaluation of beta-blockade associated with atenolol in healthy dogs. Master’s Thesis, Virginia Polytechnic Institute and State University. http://hdl.handle.net/10919/97339 

🟢 Generic Pimobendan Compounded Oral Oil Liquid

Generic Pimobendan Compounded Oral Oil Liquid

Drugs

Heart

View on Chewy 

References and resources
  1. Hanzlicek AS, Gehring R, Kukanich B, Kukanich KS, Borgarelli M, Smee N, Olson EE, Margiocco M. Pharmacokinetics of oral pimobendan in healthy cats. J Vet Cardiol. 2012 Dec;14(4):489-96. doi:10.1016/j.jvc.2012.06.002 
  2. Kittleson MD, Côté E. The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy. Journal of Feline Medicine and Surgery. 2021;23(11):1028-1051. doi:10.1177/1098612X211020162 
  3. Oldach MS, Ueda Y, Ontiveros ES, Fousse SL, Harris SP and Stern JA (2019) Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study. Front. Vet. Sci. 6:15. doi:10.3389/fvets.2019.00015 
  4. Oldach, M.S., Ueda, Y., Ontiveros, E.S. et al. Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy. BMC Vet Res 17, 89 (2021). doi:10.1186/s12917-021-02799-9 
  5. Reina-Doreste Y, Stern JA, Keene BW, Tou SP, Atkins CE, DeFrancesco TC, Ames MK, Hodge TE, Meurs KM. Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure. J Am Vet Med Assoc. 2014 Sep 1;245(5):534-9. doi:10.2460/javma.245.5.534 
  6. Schober KE, Rush JE, Luis Fuentes V, et al. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study. J Vet Intern Med. 2021; 35: 789-800. doi:10.1111/jvim.16054 
  7. Pimobendan Use in Cats. Today’s Veterinary Practice. 2018. https://todaysveterinarypractice.com/wp-content/uploads/sites/4/2018/06/Pimobendan-Use-in-Cats.pdf 

🟢 MDF Instruments Acoustica Lightweight Stethoscope

MDF Instruments Acoustica Lightweight Stethoscope

Heart

Monitoring

View on Amazon  💲 | MDF Instruments 

😺 Luna Says

My dad really likes listening to my fluffy little heart with this. I don’t think I’ll ever understand humans…

🟢 NOW Taurine Pure Powder

NOW Taurine Pure Powder

Heart

Supplements

View on Amazon  💲 | Vitacost  | NOW Foods 

References and resources
  1. Burns K (2022). Feline Hypertrophic Cardiomyopathy and the Role of Nutrition. Today’s Veterinary Nurse. https://todaysveterinarynurse.com/nutrition/feline-hypertrophic-cardiomyopathy-and-the-role-of-nutrition/ 

🟢 Rapamycin for Cats

CKD

Drugs

Heart

View on Helping Pets Live Longer 

References and resources
  1. Kaplan JL, Rivas VN, Walker AL, Grubb L, Farrell A, Fitzgerald S, Kennedy S, Jauregui CE, Crofton AE, McLaughlin C, Van Zile R, DeFrancesco TC, Meurs KM, Stern JA. Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic cardiomyopathy: results of the RAPACAT trial. J Am Vet Med Assoc. 2023 Jul 26;261(11):1628-1637. doi:10.2460/javma.23.04.0187 

🟢 Rx Vitamins Formula CV Capsules Heart Supplement (90 ct)

Rx Vitamins Formula CV Capsules Heart Supplement

🛑 This item has cautions. See the references and resources.

Heart

Supplements

View on Amazon  💲 | Chewy  | VetRxDirect  | Rx Vitamins 

References and resources
  1. “Do no use simultaneously with anticoagulants, antihypertensive, vasodilators, or if suffering from ulcers, diabetes and when pregnant or breastfeeding.” — Cunha J. Forskolin. https://www.rxlist.com/forskolin/generic-drug.htm  (retrieved 2024-10-20)
  2. “Because supplementation with Coleus forskohlii extract or forskolin has been noted to reduce blood pressure, increase stomach acid levels, and inhibit platelet aggregation, it should be used with caution by people with hypotension (low blood pressure) or who are taking antihypertensive (blood-pressure-lowering) drugs, people with blood clotting disorders or who are taking blood thinning medication, and people with stomach ulcers.” — Damianou A, Milazzo N (2024). Coleus forskohlii. https://examine.com/supplements/coleus-forskohlii/#dosage-information  (retrieved 2024-10-20)
  3. “Forskolin should be avoided in patients with polycystic kidney disease.” — Forskolin. https://www.drugs.com/npc/forskolin.html  (retrieved 2024-10-20)

🟢 Tap Tool Pro

Tap Tool Pro

Apps

Heart

Monitoring

manufacturer page 

View on App Store  | Play Store 

😺 Luna Says

Dad uses this app to measure my respiratory and heart rates. When he evaluated several apps for this purpose, he found this one to be simplest, easiest to use, as well as most accurate.

🟢 Tiki Cat Silver Comfort Mousse, Chicken & Chicken Liver

Tiki Cat Silver Comfort Mousse, Chicken & Chicken Liver

Heart

Pilling

Treats

manufacturer page 

20 ct

View on Amazon  💲 | Chewy 

160 ct

View on Amazon  💲

😺 Luna Says

This works very well for smothering capsules, or even plain as a chaser after those nasty oral medicines. (Gross!) I heard Dad mumble something about low sodium and the cardiologist.

🟢 Vetmedin Pimobendan Chewable Tablets

Vetmedin Pimobendan Chewable Tablets

Drugs

Heart

View on Chewy 

References and resources
  1. Vetmedin (pimobendan) Chewable Tablets product insert. Boehringer Ingelheim Animal Health USA Inc. 2023. https://docs.boehringer-ingelheim.com/PI/Theras/Vetmedin_PI.pdf 
  2. Freedom of Information Summary, Corrected Original New Animal Drug Application, NADA 141-273: Vetmedin (pimobendan) Chewable Tablets. 2007. https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/832 
  3. Freedom of Information Summary, Application for Conditional Approval, Application Number 141-556: Vetmedin-CA1 (pimobendan) Chewable Tablets. 2022. https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/12512 
  4. Freedom of Information Summary, Original New Animal Drug Application, NADA 141-575: Vetmedin Solution (pimobendan oral solution). 2024. https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15024 
  5. Hanzlicek AS, Gehring R, Kukanich B, Kukanich KS, Borgarelli M, Smee N, Olson EE, Margiocco M. Pharmacokinetics of oral pimobendan in healthy cats. J Vet Cardiol. 2012 Dec;14(4):489-96. doi:10.1016/j.jvc.2012.06.002 
  6. Kittleson MD, Côté E. The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy. Journal of Feline Medicine and Surgery. 2021;23(11):1028-1051. doi:10.1177/1098612X211020162 
  7. Oldach MS, Ueda Y, Ontiveros ES, Fousse SL, Harris SP and Stern JA (2019) Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study. Front. Vet. Sci. 6:15. doi:10.3389/fvets.2019.00015 
  8. Oldach, M.S., Ueda, Y., Ontiveros, E.S. et al. Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy. BMC Vet Res 17, 89 (2021). doi:10.1186/s12917-021-02799-9 
  9. Reina-Doreste Y, Stern JA, Keene BW, Tou SP, Atkins CE, DeFrancesco TC, Ames MK, Hodge TE, Meurs KM. Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure. J Am Vet Med Assoc. 2014 Sep 1;245(5):534-9. doi:10.2460/javma.245.5.534 
  10. Schober KE, Rush JE, Luis Fuentes V, et al. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study. J Vet Intern Med. 2021; 35: 789-800. doi:10.1111/jvim.16054 
  11. Pimobendan Use in Cats. Today’s Veterinary Practice. 2018. https://todaysveterinarypractice.com/wp-content/uploads/sites/4/2018/06/Pimobendan-Use-in-Cats.pdf 

Heart references and resources

  1. Amabile CM, Spencer AP. Keeping your patient with heart failure safe: a review of potentially dangerous medications. Arch Intern Med. 2004 Apr 12;164(7):709-20. doi:10.1001/archinte.164.7.709 
  2. Brainard BM, Coleman AE, Kurosawa A, Rush JE, Hogan DF, Brooks MB, Kraus MS. Therapy with clopidogrel or rivaroxaban has equivalent impacts on recurrence of thromboembolism and survival in cats following cardiogenic thromboembolism: the SUPERCAT study. J Am Vet Med Assoc. 2024 Dec 18;263(4):1-10. doi:10.2460/javma.24.09.0584 
  3. Burns K (2022). Feline Hypertrophic Cardiomyopathy and the Role of Nutrition. Today’s Veterinary Nurse. https://todaysveterinarynurse.com/nutrition/feline-hypertrophic-cardiomyopathy-and-the-role-of-nutrition/ 
  4. Cook A, Saunders A. Finding the Balance in Your Patients with Cardiovascular and Renal Disease. Today’s Veterinary Practice. 2018. https://todaysveterinarypractice.com/cardiology/veterinary-patients-with-cardiovascular-and-renal-disease/ 
  5. Hansen B (2021). Fluid Overload. Front. Vet. Sci. 8:668688. doi:10.3389/fvets.2021.668688 
  6. Heine GH, Seiler S, Fliser D. FGF-23: the rise of a novel cardiovascular risk marker in CKD. Nephrol Dial Transplant. 2012 Aug;27(8):3072-81. doi:10.1093/ndt/gfs259 
  7. Iqbal MA, Gupta M. Cardiogenic Pulmonary Edema. [Updated 2023 Apr 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK544260/ 
  8. Kaplan JL, Rivas VN, Walker AL, Grubb L, Farrell A, Fitzgerald S, Kennedy S, Jauregui CE, Crofton AE, McLaughlin C, Van Zile R, DeFrancesco TC, Meurs KM, Stern JA. Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic cardiomyopathy: results of the RAPACAT trial. J Am Vet Med Assoc. 2023 Jul 26;261(11):1628-1637. doi:10.2460/javma.23.04.0187 
  9. Kittleson M. Treatment of Feline Hypertrophic Cardiomyopathy - Lost Dreams. World Small Animal Veterinary Association World Congress Proceedings, 2014. https://www.vin.com/doc/?id=7054765 
  10. Page RL 2nd, O’Bryant CL, Cheng D, Dow TJ, Ky B, Stein CM, Spencer AP, Trupp RJ, Lindenfeld J; American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical Cardiology; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Drugs That May Cause or Exacerbate Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2016 Aug 9;134(6):e32-69. doi:10.1161/CIR.0000000000000426 
  11. Pierce, K.V., Rush, J.E., Freeman, L.M., Cunningham, S.M. and Yang, V.K. (2017), Association between Survival Time and Changes in NT-proBNP in Cats Treated for Congestive Heart Failure. J Vet Intern Med, 31: 678-684. doi:10.1111/jvim.14690 
  12. Rivas VN, Kaplan JL, Kennedy SA, Fitzgerald S, Crofton AE, Farrell A, Grubb L, Jauregui CE, Grigorean G, Choi E, et al. Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study. Animals. 2023; 13(20):3184. doi:10.3390/ani13203184 
  13. Schaer M. Fluid Therapy for Critically Ill Dogs and Cats. World Small Animal Veterinary Association World Congress Proceedings, 2006. https://www.vin.com/doc/?id=3858919 
  14. Syme HM. Cardiovascular and renal manifestations of hyperthyroidism. Vet Clin North Am Small Anim Pract. 2007 Jul;37(4):723-43, vi. doi:10.1016/j.cvsm.2007.05.011 
  15. Wohlfahrt P, Melenovsky V, Kotrc M, Benes J, Jabor A, Franekova J, Lemaire S, Kautzner J, Jarolim P. Association of Fibroblast Growth Factor-23 Levels and Angiotensin-Converting Enzyme Inhibition in Chronic Systolic Heart Failure. JACC Heart Fail. 2015 Oct;3(10):829-39. doi:10.1016/j.jchf.2015.05.012 
  16. Zhang Y, He D, Zhang W, Xing Y, Guo Y, Wang F, Jia J, Yan T, Liu Y, Lin S. ACE Inhibitor Benefit to Kidney and Cardiovascular Outcomes for Patients with Non-Dialysis Chronic Kidney Disease Stages 3-5: A Network Meta-Analysis of Randomised Clinical Trials. Drugs. 2020 Jun;80(8):797-811. doi:10.1007/s40265-020-01290-3 

👉 Product links on this page marked with a 💲 may earn the site a modest commission.

Something missing? Questions, comments, or corrections? Email chuck -at- weathermuffin.com

Disclaimers: While I have strived to include only products which I have used or would use with my own CKD kitty, appearance here should not be construed as endorsement. Every kitty and every kitty's situation is unique. This web site's operator is not responsible for your cat's well-being; you alone are. Do not start, stop, or adjust any medications or supplements without consulting with your veterinarian.

© 2024-2025 Weathermuffin, LLC