Pyelonephritis

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🟢 Baytril enrofloxacin

A kidney-penetrating fluoroquinolone antibiotic.

🛑 This item has cautions. See the references and resources.

Antibiotics

Pyelonephritis

UTI

manufacturer page  Tanya’s info 

References and resources

1. Baytril product insert. Elanco, 2022. PDF 
2. “Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures.” — Baytril manufacturer web page. Elanco, 2024. https://my.elanco.com/us/baytril  (retrieved 2024-11-01)
3. “The use of fluoroquinolones in cats has been reported to adversely affect the retina. Such products should be used with caution in cats.” — Baytril manufacturer web page. Elanco, 2024. https://my.elanco.com/us/baytril  (retrieved 2024-11-01)
4. M.M. Ford, K. Narfstrom, R.R. Dubielzig, E.A. Giuliano, C.P. Moore; Enrofloxacin and the Feline Retina. Invest. Ophthalmol. Vis. Sci. 2004;45(13):5072. https://iovs.arvojournals.org/article.aspx?articleid=2410586 
5. Ford MM, Dubielzig RR, Giuliano EA, Moore CP, Narfström KL. Ocular and systemic manifestations after oral administration of a high dose of enrofloxacin in cats. Am J Vet Res. 2007 Feb;68(2):190-202. doi:10.2460/ajvr.68.2.190 
6. Foster JD, Abouraya M, Papich MG, Muma NA. Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function. J Vet Intern Med. 2023 Nov-Dec;37(6):2230-2240. doi:10.1111/jvim.16866 
7. Gelatt KN, van der Woerdt A, Ketring KL, Andrew SE, Brooks DE, Biros DJ, Denis HM, Cutler TJ. Enrofloxacin-associated retinal degeneration in cats. Vet Ophthalmol. 2001 Jun;4(2):99-106. doi:10.1046/j.1463-5224.2001.00182.x 
8. Hwang YH, Kim MS, Song IB, Lim JH, Park BK, Yun HI. Altered pharmacokinetics of enrofloxacin in experimental models of hepatic and renal impairment. Vet Res Commun. 2009 Jun;33(5):481-7. doi:10.1007/s11259-008-9195-y 
9. “Avoid enrofloxacin in cats with CKD due to increased risk of retinopathy at standard therapeutic doses” — Sparkes AH, Caney S, Chalhoub S, Elliott J, Finch N, Gajanayake I, Langston C, Lefebvre HP, White J, Quimby J. ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease. J Feline Med Surg. 2016 Mar;18(3):219-39. doi:10.1177/1098612X16631234  (retrieved 2024-04-02)
10. “Dosage adjustments may be particularly important for enrofloxacin, which appears to be more retinotoxic in cats” — Trepanier LA. Feline Therapeutics. World Small Animal Veterinary Association World Congress Proceedings, 2013. https://www.vin.com/doc/?id=5709852  (retrieved 2024-11-01)
11. Wiebe V, Hamilton P. Fluoroquinolone-induced retinal degeneration in cats. J Am Vet Med Assoc. 2002 Dec 1;221(11):1568-71. doi:10.2460/javma.2002.221.1568 

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🟢 Zeniquin marbofloxacin tablets (25 mg, 1 ct)

A kidney-penetrating fluoroquinolone antibiotic.

🛑 This item has cautions. See the references and resources.

Antibiotics

Pyelonephritis

UTI

manufacturer page  Tanya’s info 

View on Chewy 

References and resources

1. Albarellos GA, Montoya L, Landoni MF. Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats. Vet J. 2005 Sep;170(2):222-9. doi:10.1016/j.tvjl.2004.05.011 
2. Freedom of Information Summary, Supplemental Approval for Use in Cats, NADA 141-151: Zeniquin (marbofloxacin) Tablets. Pfizer Inc. 2001. https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/668 
3. “Adjust dose in moderate or severe CKD (IRIS stages 3 and 4)” — Sparkes AH, Caney S, Chalhoub S, Elliott J, Finch N, Gajanayake I, Langston C, Lefebvre HP, White J, Quimby J. ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease. J Feline Med Surg. 2016 Mar;18(3):219-39. doi:10.1177/1098612X16631234  (retrieved 2024-04-02)
4. “Fluoroquinolones … are renally cleared. … they do cause dose-dependent retinal toxicity in cats. Therefore, dosage adjustments for fluoroquinolones may be important in cats with renal insufficiency … extending the dosing interval may be most appropriate, since fluoroquinolones are also concentration-dependent.” — Trepanier LA. Feline Therapeutics. World Small Animal Veterinary Association World Congress Proceedings, 2013. https://www.vin.com/doc/?id=5709852  (retrieved 2024-11-01)
5. Wiebe V, Hamilton P. Fluoroquinolone-induced retinal degeneration in cats. J Am Vet Med Assoc. 2002 Dec 1;221(11):1568-71. doi:10.2460/javma.2002.221.1568 
6. Zeniquin product insert. Zoetis, 2019. PDF 
7. “Quinolones should be used with caution in animals with known or suspected central nervous system (CNS) disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures.” — Zeniquin product insert. Zoetis, 2019. PDF  (retrieved 2024-11-01)
8. “The use of fluoroquinolones in cats has been reported to adversely affect the retina. Such products should be used with caution in cats.” — Zeniquin product insert. Zoetis, 2019. PDF  (retrieved 2024-11-01)

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