Pain

Updated March 28, 2025.

🟢 Dechra Redonyl Ultra Feline

Dechra Redonyl Ultra Feline

The acronym “PEA” used here refers to palmitoylethanolamide, and should not be confused with phenylethylamine.

🛑 This item has cautions. See the references and resources.

Arthritis

Pain

Palmitoylethanolamide (PEA)

manufacturer page 

View on VetRxDirect 

😺 Luna Says

Dad thinks this helps me with arthritis and other pain. He was unable to find another source which is “ultra-micronized,” which allegedly helps with something called “bioavailability.” Silly humans and their fancy words! Just mix this in my food already.

References and resources
  1. Cifelli P, Ruffolo G, Ceccanti M, Cambieri C, Libonati L, Palma E, Inghilleri M. Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function. Biomolecules. 2022; 12(6):758. doi:10.3390/biom12060758 
  2. “Contains boric acid < 0.1% by weight.” — Redonyl Ultra Feline Powder Safety Data Sheet. Dechra. 2020. https://www.dechra-us.com/Admin/Public/Download.aspx?file=Files%2FFiles%2FProductDownloads%2FUS%2FRedonyl_Feline_SDS.pdf  (retrieved 2025-03-02)
  3. Rusbridge C. Neuropathic pain in cats: mechanisms and multimodal management. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241246518 
  4. “Due to the patents held on Redonyl Ultra, no other animal health nutraceutical can contain micronized or ultramicronized PEA.” — Dechra unveils skin-supporting Redonyl Ultra Feline (2022) https://todaysveterinarybusiness.com/redonyl-ultra-feline-dechra/  (retrieved 2024-10-20)

🟢 Feline Grimace Scale

Feline Grimace Scale

Apps

Pain

manufacturer page 

View on App Store  | Play Store 

😺 Luna Says

Use this handy app to learn and quantify signs of pain in cats.

🟢 Generic Gabapentin Compounded Tablet

Generic Gabapentin Compounded Tablet

Anxiety

Drugs

Pain

View on Chewy 

References and resources
  1. Adrian D, Papich MG, Baynes R, Stafford E, Lascelles BDX. The pharmacokinetics of gabapentin in cats. J Vet Intern Med. 2018; 32: 1996-2002. doi:10.1111/jvim.15313 
  2. Buckley C, Griffin C, Anderson H, Moore SA. Presumed gabapentin-induced myoclonus in two cats. JFMS Open Rep. 2024 Nov 28;10(2):20551169241273634. doi:10.1177/20551169241273634 
  3. Di Cesare F, Negro V, Ravasio G, Villa R, Draghi S, Cagnardi P. Gabapentin: Clinical Use and Pharmacokinetics in Dogs, Cats, and Horses. Animals. 2023; 13(12):2045. doi:10.3390/ani13122045 
  4. Fantinati M, Trnka J, Signor A, et al. Appetite-stimulating effect of gabapentin vs mirtazapine in healthy cats post-ovariectomy. Journal of Feline Medicine and Surgery. 2020;22(12):1176-1183. doi:10.1177/1098612X20916391 
  5. Guedes AGP, Meadows JM, Pypendop BH, Johnson EG, Zaffarano B. Assessment of the effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life in osteoarthritic geriatric cats. J Am Vet Med Assoc. 2018 Sep 1;253(5):579-585. doi:10.2460/javma.253.5.579 
  6. Kaufman KR, Parikh A, Chan L, Bridgeman M, Shah M. Myoclonus in renal failure: Two cases of gabapentin toxicity. Epilepsy Behav Case Rep. 2013 Dec 29;2:8-10. doi:10.1016/j.ebcr.2013.12.002 
  7. Madan RD, Cenani A, Montgomery E, Azevedo T, Vernau KM, Brosnan RJ. Pregabalin produces similar effects as gabapentin for preanesthetic sedation in cats. J Am Vet Med Assoc. 2023 Dec 22;262(3):359-363. doi:10.2460/javma.23.09.0493 
  8. Miller A, Price G. Gabapentin toxicity in renal failure: the importance of dose adjustment. Pain Med. 2009 Jan;10(1):190-2. doi:10.1111/j.1526-4637.2008.00492.x 
  9. Quimby JM, Lorbach SK, Saffire A, et al. Serum concentrations of gabapentin in cats with chronic kidney disease. Journal of Feline Medicine and Surgery. 2022;24(12):1260-1266. doi:10.1177/1098612X221077017 
  10. Quimby JM, Jones SE, Saffire A, et al. Assessment of the effect of gabapentin on blood pressure in cats with and without chronic kidney disease. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241240326 
  11. Rusbridge C. Neuropathic pain in cats: mechanisms and multimodal management. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241246518 
  12. Siao KT, Pypendop BH, Ilkiw JE. Pharmacokinetics of gabapentin in cats. Am J Vet Res. 2010 Jul;71(7):817-21. doi:10.2460/ajvr.71.7.817 
  13. Vanderhoof C. Gabapentin for Cats: A Common Option for Pain and Anxiety. GoodRx. 2024. https://www.goodrx.com/pet-health/cat/gabapentin-for-cats 
  14. Zand L, McKian KP, Qian Q. Gabapentin toxicity in patients with chronic kidney disease: a preventable cause of morbidity. Am J Med. 2010 Apr;123(4):367-73. doi:10.1016/j.amjmed.2009.09.030 
  15. Zour E, Lodhi SA, Nesbitt RU, Silbering SB, Chaturvedi PR. Stability studies of gabapentin in aqueous solutions. Pharm Res. 1992 May;9(5):595-600. doi:10.1023/a:1015833622943 

🟢 Zoetis Bonqat

Zoetis Bonqat

Anxiety

Drugs

Pain

manufacturer page 

References and resources
  1. Lamminen T, Doedée A, Hyttilä-Hopponen M, Kaskinoro J. Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats. J Vet Pharmacol Ther. 2022 Jul;45(4):385-391. doi:10.1111/jvp.13061 
  2. Mayoral V, Galvez R, Ferrándiz M, Miguéns Vázquez X, Cordero-García C, Alcántara Montero A, Pérez C, Pérez-Páramo M. Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety. Front Pain Res (Lausanne). 2025 Jan 7;5:1513597. doi:10.3389/fpain.2024.1513597 
  3. Rusbridge C. Pregabalin - 5 things you should know about prescribing in dogs and cats. 2023. https://youtu.be/fr3gu6S6guE 

🟢 Zoetis Solensia

Zoetis Solensia

Arthritis

Drugs

Pain

manufacturer page  Tanya’s info 

References and resources
  1. Committee for Medicinal Products for Veterinary Use. CVMP assessment report for Solensia (Common name: frunevetmab). European Medicines Agency. 2021. https://medicines.health.europa.eu/veterinary/fr/documents/download/e4618d2b-2d4f-411c-be83-5295aed8d8a1 
  2. Gruen ME, Myers JAE, Lascelles BDX. Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of Degenerative Joint Disease-Associated Chronic Pain in Cats: A Multisite Pilot Field Study. Front Vet Sci. 2021 May 28;8:610028. doi:10.3389/fvets.2021.610028 
  3. Menges S, Michaelis M, Kleinschmidt-Dörr K. Anti-NGF treatment worsens subchondral bone and cartilage measures while improving symptoms in floor-housed rabbits with osteoarthritis. Front Physiol. 2023 Jun 26;14:1201328. doi:10.3389/fphys.2023.1201328 
  4. Miller RE, Block JA, Malfait AM. Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models? Curr Opin Rheumatol. 2017 Jan;29(1):110-118. doi:10.1097/BOR.0000000000000354 
  5. Storrer A, Mackie JT, Gunew MN, Aslan J. Cutaneous lesions and clinical outcomes in five cats after frunevetmab injections. J Feline Med Surg. 2023 Nov;25(11):1098612X231198416. doi:10.1177/1098612X231198416 
  6. Solensia (frunevetmab injection) Product Insert. Zoeits. August 2021. https://www.zoetisus.com/content/_assets/docs/vmips/package-inserts/solensia-prescribing-information.pdf 
  7. Freedom of Information Summary, Original New Animal Drug Application, NADA 141-546: Solensia (frunevetmab) Injectable Solution for Cats. Zoetis Inc. 2022. https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11817 

Pain references and resources

  1. Chronic Pain Educational Toolkit. American Association of Feline Practitioners. 2024. https://catvets.com/chronic-pain-toolkit 
  2. Delsart A, Castel A, Dumas G, Otis C, Lachance M, Barbeau-Grégoire M, Lussier B, Péron F, Hébert M, Lapointe N, Moreau M, Martel-Pelletier J, Pelletier JP, Troncy E. Non-invasive electroencephalography in awake cats: Feasibility and application to sensory processing in chronic pain. J Neurosci Methods. 2024 Nov;411:110254. doi:10.1016/j.jneumeth.2024.110254 
  3. Jordan DG, Ray JD. Management of Chronic Pain in Cats. Today’s Veterinary Practice. 2012. https://todaysveterinarypractice.com/pain_management/focus-on-pharmacology-management-of-chronic-pain-in-cats/ 
  4. KuKanich B. Outpatient oral analgesics in dogs and cats beyond nonsteroidal antiinflammatory drugs: an evidence-based approach. Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1109-25. doi:10.1016/j.cvsm.2013.04.007 
  5. Monteiro BP, Steagall PV. Chronic pain in cats: Recent advances in clinical assessment. Journal of Feline Medicine and Surgery. 2019;21(7):601-614. doi:10.1177/1098612X19856179 
  6. Monteiro, B.P., Lascelles, B.D.X., Murrell, J., Robertson, S., Steagall, P.V.M. and Wright, B. (2023), 2022 WSAVA guidelines for the recognition, assessment and treatment of pain. J Small Anim Pract, 64: 177-254. doi:10.1111/jsap.13566 
  7. Quimby JM. Maropitant Use in Cats. Today’s Veterinary Practice. 2020. https://todaysveterinarypractice.com/pharmacology/maropitant-use-in-cats/ 
  8. Rusbridge C. Neuropathic pain in cats: mechanisms and multimodal management. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241246518 
  9. Vanderhoof C. Gabapentin for Cats: A Common Option for Pain and Anxiety. GoodRx. 2024. https://www.goodrx.com/pet-health/cat/gabapentin-for-cats 

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