Palmitoylethanolamide (PEA)

Updated March 28, 2025.

🟢 Dechra Redonyl Ultra Feline

The acronym “PEA” used here refers to palmitoylethanolamide, and should not be confused with phenylethylamine.

🛑 This item has cautions. See the references and resources.

Arthritis

Pain

Palmitoylethanolamide (PEA)

manufacturer page 

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😺 Luna Says

Dad thinks this helps me with arthritis and other pain. He was unable to find another source which is “ultra-micronized,” which allegedly helps with something called “bioavailability.” Silly humans and their fancy words! Just mix this in my food already.

References and resources

1. Cifelli P, Ruffolo G, Ceccanti M, Cambieri C, Libonati L, Palma E, Inghilleri M. Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function. Biomolecules. 2022; 12(6):758. doi:10.3390/biom12060758 
2. “Contains boric acid < 0.1% by weight.” — Redonyl Ultra Feline Powder Safety Data Sheet. Dechra. 2020. https://www.dechra-us.com/Admin/Public/Download.aspx?file=Files%2FFiles%2FProductDownloads%2FUS%2FRedonyl_Feline_SDS.pdf  (retrieved 2025-03-02)
3. Rusbridge C. Neuropathic pain in cats: mechanisms and multimodal management. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241246518 
4. “Due to the patents held on Redonyl Ultra, no other animal health nutraceutical can contain micronized or ultramicronized PEA.” — Dechra unveils skin-supporting Redonyl Ultra Feline (2022) https://todaysveterinarybusiness.com/redonyl-ultra-feline-dechra/  (retrieved 2024-10-20)

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Palmitoylethanolamide (PEA) references and resources

1. Cifelli P, Ruffolo G, Ceccanti M, Cambieri C, Libonati L, Palma E, Inghilleri M. Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function. Biomolecules. 2022; 12(6):758. doi:10.3390/biom12060758 
2. Paul Clayton, Silma Subah, Ruchitha Venkatesh, Mariko Hill & Nathasha Bogoda (2021) Palmitoylethanolamide: A Potential Alternative to Cannabidiol, Journal of Dietary Supplements, 20:3, 505-530. doi:10.1080/19390211.2021.2005733 
3. Clayton P, Hill M, Bogoda N, Subah S, Venkatesh R. Palmitoylethanolamide: A Natural Compound for Health Management. International Journal of Molecular Sciences. 2021; 22(10):5305. doi:10.3390/ijms22105305 
4. della Rocca G, Re G. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art. Biomolecules. 2022; 12(9):1186. doi:10.3390/biom12091186 
5. Guida, F., Luongo, L., Boccella, S. et al. Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor. Sci Rep 7, 375 (2017). doi:10.1038/s41598-017-00342-1 
6. Hesselink JMK (2013) Professor Rita Levi-Montalcini on Nerve Growth Factor, Mast Cells and Palmitoylethanolamide, an Endogenous Anti-Inflammatory and Analgesic Compound. J Pain Relief 2:114. doi:10.4172/2167-0846.1000114 
7. Impellizzeri, D., Bruschetta, G., Cordaro, M. et al. Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain. J Neuroinflammation 11, 136 (2014). doi:10.1186/s12974-014-0136-0 
8. Lang-Illievich K, Klivinyi C, Lasser C, Brenna CTA, Szilagyi IS, Bornemann-Cimenti H. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023; 15(6):1350. doi:10.3390/nu15061350 
9. Noli, C., della Valle, M.F., Miolo, A., Medori, C., Schievano, C. and (2019), Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double-blind, multicentre, randomized, placebo-controlled study. Vet Dermatol, 30: 387-e117. doi:10.1111/vde.12764 
10. Redlich S, Ribes S, Schütze S, Nau R. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. J Neuroinflammation. 2014 Jun 14;11:108. doi:10.1186/1742-2094-11-108 
11. Rusbridge C. Palmitoylethanolamide (PEA) for neuropathic pain in dogs and cats. 2023. https://youtu.be/MQQJzhT8yxY 
12. Rusbridge C. Neuropathic pain in cats: mechanisms and multimodal management. Journal of Feline Medicine and Surgery. 2024;26(5). doi:10.1177/1098612X241246518 

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